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The oldest protein scare is that eating more protein wears out your kidneys. Dr. Jordan Feigenbaum takes it apart with the actual evidence: what protein does to a healthy kidney, why an estimated GFR can make a muscular person look sick, what the landmark low-protein trials (MDRD, the 2020 Cochrane review) really found, and why in real kidney disease it's the red meat and the whole dietary pattern that track with harm more than the protein number. It ends on the muscle-and-lifting tradeoff most low-protein advice ignores. This is the kidney segment from Episode 407, The Protein Scaries. Chapters 00:00 What protein does to a healthy kidney 00:54 Why estimated GFR can mislead 01:41 Where the scare came from (Brenner, 1982) 02:12 Healthy kidneys under higher protein 04:19 Chronic kidney disease: does low protein help? 06:30 Diabetes, and it's really the dietary pattern 07:34 Red meat, not total protein (Time to Move On) 08:39 Lab surrogates vs. what patients feel 09:57 Why lifting matters on a restricted diet 11:32 The bottom line on kidneys Resources: Barbell Medicine coaching and templates: https://www.barbellmedicine.com Plus podcast subscription: https://www.barbellmedicine.com/shop/subscriptions/plus-podcast-subscription/ Barbell Medicine Premium: https://www.barbellmedicine.com/shop/subscriptions/barbell-medicine-premium/ Signal (book pre-order): https://www.barbellmedicine.com/shop/learning/signal/ Our Protein Content: https://www.barbellmedicine.com/blog/protein-and-weight-loss/ https://www.barbellmedicine.com/blog/protein-on-ozempic/ https://www.barbellmedicine.com/blog/barbell-medicine-protein-recommendations/ Studies Levine et al. Cell Metabolism 2014. doi:10.1016/j.cmet.2014.02.006 Naghshi et al. BMJ 2020. doi:10.1136/bmj.m2412 Devries et al. J Nutr 2018. doi:10.1093/jn/nxy197 Antonio et al. J Nutr Metab 2016. doi:10.1155/2016/9104792 Knight et al. Ann Intern Med 2003. doi:10.7326/0003-4819-138-6-200303180-00009 Klahr et al. (MDRD). NEJM 1994. doi:10.1056/NEJM199403313301301 Hahn, Hodson & Fouque. Cochrane 2020. doi:10.1002/14651858.CD001892.pub5 Obeid, Hiremath & Topf. Kidney360 2022. doi:10.34067/KID.0001002022 Lew et al. J Am Soc Nephrol 2017. doi:10.1681/ASN.2016030248 Castaneda et al. Ann Intern Med 2001. doi:10.7326/0003-4819-135-11-200112040-00008 Bauer et al. (PROT-AGE). JAMDA 2013. doi:10.1016/j.jamda.2013.05.021 Fenton et al. Nutrition Journal 2011. doi:10.1186/1475-2891-10-41 Shams-White et al. Am J Clin Nutr 2017. doi:10.3945/ajcn.116.145110 Witard et al. Am J Clin Nutr 2013. doi:10.3945/ajcn.112.055517 Macnaughton et al. Physiol Rep 2016. doi:10.14814/phy2.12893 Trommelen et al. Cell Reports Medicine 2023. doi:10.1016/j.xcrm.2023.101324 Wycherley et al. Am J Clin Nutr 2012. doi:10.3945/ajcn.112.044321 Moore et al. JAMA Intern Med 2016. doi:10.1001/jamainternmed.2016.1548 Larsson et al. Cancer Med 2020. doi:10.1002/cam4.3345 Brenner, Meyer & Hostetter. NEJM 1982. doi:10.1056/NEJM198209093071104 Chan et al. PLoS One 2011. doi:10.1371/journal.pone.0020456 Berryman et al. Am J Clin Nutr 2018. doi:10.1093/ajcn/nqy088 Morton et al. Br J Sports Med 2018. doi:10.1136/bjsports-2017-097608

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